7 January
Posted by jane
| Research article | http://www.biomedcentral.com/graphics/flashes/openaccess-large.gif (http://www.biomedcentral.com/info/about/openaccess/). (http://creativecommons.org/licenses/by/2.0) |
Man Wai Ng http://www.biomedcentral.com/graphics/article/email.gif (http://www.biomedcentral.com/logon/logon.asp?msg=ce), Gangqiao Zhou http://www.biomedcentral.com/graphics/article/email.gif (http://www.biomedcentral.com/logon/logon.asp?msg=ce), Wai Po Chong http://www.biomedcentral.com/graphics/article/email.gif (http://www.biomedcentral.com/logon/logon.asp?msg=ce), Loretta Wing Yan Lee http://www.biomedcentral.com/graphics/article/email.gif (http://www.biomedcentral.com/logon/logon.asp?msg=ce), Helen Ka Wai Law http://www.biomedcentral.com/graphics/article/email.gif (http://www.biomedcentral.com/logon/logon.asp?msg=ce), Hongxing Zhang http://www.biomedcentral.com/graphics/article/email.gif (http://www.biomedcentral.com/logon/logon.asp?msg=ce), Wilfred Hing Sang Wong http://www.biomedcentral.com/graphics/article/email.gif (http://www.biomedcentral.com/logon/logon.asp?msg=ce), Susanna Fung Shan Fok http://www.biomedcentral.com/graphics/article/email.gif (http://www.biomedcentral.com/logon/logon.asp?msg=ce), Yun Zhai http://www.biomedcentral.com/graphics/article/email.gif (http://www.biomedcentral.com/logon/logon.asp?msg=ce), Raymond WH Yung http://www.biomedcentral.com/graphics/article/email.gif (http://www.biomedcentral.com/logon/logon.asp?msg=ce), Eudora Y Chow http://www.biomedcentral.com/graphics/article/email.gif (http://www.biomedcentral.com/logon/logon.asp?msg=ce), Ka Leung Au http://www.biomedcentral.com/graphics/article/email.gif (http://www.biomedcentral.com/logon/logon.asp?msg=ce), Eric YT Chan http://www.biomedcentral.com/graphics/article/email.gif (http://www.biomedcentral.com/logon/logon.asp?msg=ce), Wilina Lim http://www.biomedcentral.com/graphics/article/email.gif (http://www.biomedcentral.com/logon/logon.asp?msg=ce), J S Malik Peiris http://www.biomedcentral.com/graphics/article/email.gif (http://www.biomedcentral.com/logon/logon.asp?msg=ce), Fuchu He http://www.biomedcentral.com/graphics/article/email.gif (http://www.biomedcentral.com/logon/logon.asp?msg=ce) and Yu Lung Lau http://www.biomedcentral.com/graphics/article/email.gif (http://www.biomedcentral.com/logon/logon.asp?msg=ce)
BMC Infectious Diseases 2007, 7:50 doi:10.1186/1471-2334-7-50
| Published | 1 June 2007 |
Abstract (provisional)
The complete article is available as a provisional PDF (http://www.biomedcentral.com/content/pdf/1471-2334-7-50.pdf). The fully formatted PDF and HTML versions are in production.
Background
Chemokines play important roles in inflammation and antiviral action. We examined whether polymorphisms of RANTES, IP-10 and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).
Methods
We tested the polymorphisms of RANTES, IP-10 and Mig for their associations with SARS in 495 Hong Kong Chinese SARS patients and 578 controls. Then we tried to replicate the results in 356 Beijing Chinese SARS patients and 367 controls.
Results
RANTES -28 G allele was associated with SARS susceptibility in Hong Kong Chinese (P<0.0001, OR=2.80, 95%CI:2.11-3.71). Individuals with RANTES -28 CG and GG genotypes had a 3.28-fold (95%CI:2.32-4.64) and 3.06-fold (95%CI:1.47-6.39) increased risk of developing SARS respectively (P<0.0001). This -28 G allele conferred risk of death in a gene-dosage dependent manner (P=0.014) with CG and GG individuals having a 2.12-fold (95% CI: 1.11-4.06) and 4.01-fold (95% CI: 1.30-12.4) increased risk. For the replication of RANTES data in Beijing Chinese, the -28 G allele was not associated with susceptibility to SARS. However, -28 CG (OR=4.27, 95%CI:1.64-11.1) and GG (OR=3.34, 95%CI:0.37-30.7) were associated with admission to intensive care units or death due to SARS (P= 0.011).
Conclusion
RANTES -28 G allele plays a role in the pathogenesis of SARS.
"Chemokines play important role in cells trafficking during immune responses. Acute
respiratory viruses commonly induce inflammatory chemokines in local tissue [9]. In
the case of SARS, our previous study confirmed that SARS coronavirus induces
upregulation of a number of inflammatory chemokines.."
H5N1 has a particular immune response that involves inflammation. The more we know about other infectious diseases, the more we know about H5N1.
J.
I would suggest that reading abstracts by lay persons such as myself is fraught with difficulty. Not knowing the meaning of many, many terms lead me to gloss over this research and not look at it further.
From the main article, for instance, here are selected statements from the discussion and conclusion, with my highlighting. With F1's definition of RANTES, and this more complete story, I'm lead to a better understanding (I hope): genetic suseptibility played an important role in SARS, and may possibily play (yes, this is conjecture) an important role in other viral infections that lead to a cytokine storm.
And then, how can we indentify and reduce the level of RANTES in certain populations?
J.
________________
RANTES is responsible for the recruitment of eosinophils, lymphocytes, monocytes and basophils at the site of inflammation and is involved in many viral infections
We found that -28 G allele of RANTES associated with the susceptibility to
and death from SARS.
….
Therefore, together with our observation that -28 G allele associated with SARS, we conclude a high level of RANTES may predispose to developing SARS.
This study showed that RANTES -28 G allele was a risk factor that associated with severe clinical outcomes in both Hong Kong and Beijing Chinese SARS patients.
Too high a level of RANTES may intensify lung inflammation and lead to lymphopenia, increasing the chance of secondary infection and hence death rate among SARS patients [18,19].
Therefore, we speculate that the -28 G allele that associates with the
higher level of RANTES may enhance the inflammation and lead to severe clinical outcomes of SARS.
Indeed, RANTES -28 G allele did show a strong association with
death in Hong Kong Chinese patients with SARS (Table 5) and this observation was confirmed in Beijing Chinese that the RANTES -28 G allele was associated with admission to intensive care units or deaths due to SARS (Table 7).
In the case of SARS susceptibility, the RANTES -28 G allele was associated with Hong Kong Chinese patients only but not in Beijing Chinese patients.
It has been suggested that Chinese in southern and northern China may be genetically distinct[20,21], accounting for the different observations with regard to SARS susceptibility.
Conclusions
We demonstrated that the RANTES -28 G allele, which correlates with high RANTES production, was associated with SARS susceptibility in Hong Kong Chinese. It was also associated with adverse outcomes from SARS in both Hong Kong and Beijing Chinese. These suggest that a high RANTES level may play a role in the pathogenesis of SARS.
This is a group that misfunctions in H5N1 causing the body to, in effect, attack itself causing fatal damage to organs.
See http://www.flutrackers.com/forum/showthread.php?t=11889
so I agree with florida one about SRAS.
#If you have any other info about this subject , Please add it free.# |
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